Macrophage Scavenger Receptor 1 Protein (MSR1) (Fc Tag)

Catalog No. ABIN7321107

Recombinant Macrophage Scavenger Receptor 1 protein expressed in HEK-293 Cells.

Quick Overview for Macrophage Scavenger Receptor 1 Protein (MSR1) (Fc Tag) (ABIN7321107)

Target: Macrophage Scavenger Receptor 1 (MSR1)

Protein Type: Recombinant

Origin: Rat

Source: HEK-293 Cells

Purity: > 95 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This Macrophage Scavenger Receptor 1 protein is labelled with Fc Tag.

Purpose: Recombinant Rat MSR1/SCARA1/CD204 Protein (Fc Tag)

Sequence: Trp79-Ser454

Characteristics: A DNA sequence encoding the rat MSR1 (Trp79-Ser454) was expressed, fused with the Fc region of human IgG1 at the N-terminus.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Macrophage Scavenger Receptor 1 (MSR1)

Alternative Name: MSR1/SCARA1/CD204

Background:

Background: Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD204, MSR1 and SCARA1, is a single-pass type I I membrane protein which contains one collagen-like domain and one SRCR domain. Macrophages are distributed in all peripheral tissues and play a critical role in the first line of the innate immune defenses against bacterial infection by phagocytosis of bacterial pathogens through the macrophage scavenger receptor 1 (MSR1). MSR1 / SCARA1 is one of the membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). MSR1 / SCARA1 is also involved in chronic inflammation which is a risk factor for prostate cancer. MSR1 1 gene was identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer.

Synonym: MSR1

Molecular Weight: 69.2 kDa

NCBI Accession: NP_001178868