METAP1 Protein (Fc Tag)
Quick Overview for METAP1 Protein (Fc Tag) (ABIN7197005)
Target
See all METAP1 ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This METAP1 protein is labelled with Fc Tag.
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Purpose
- Recombinant Human METAP1 Protein (Fc Tag)
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Sequence
- Met 1-Phe 272
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Characteristics
- A DNA sequence encoding the N-terminal domain (Met 1-Phe 272) of human METAP1 (NP_055958.2) was fused with the Fc region of human IgG1 at the N-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Methionyl Aminopeptidase 1 (METAP1) (AA 1-386) protein (His tag)
METAP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Methionyl Aminopeptidase 1 (METAP1) (AA 1-272) protein (GST tag)METAP1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Methionyl Aminopeptidase 1 (METAP1) protein (Myc-DYKDDDDK Tag)METAP1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile PBS, pH 7.4
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- METAP1 (Methionyl Aminopeptidase 1 (METAP1))
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Alternative Name
- METAP1
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Background
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Background: Processing of the N-terminal initiator methionine or formylated methionine is an essential cellular process conserved from prokaryotes to eukaryotes. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. As a member of the M24 family of metalloproteases, METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents.
Synonym: Methionine aminopeptidase 1, MAP 1, MetAP 1, Peptidase M 1, METAP1,MAP1A,MetAP1A
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Molecular Weight
- 57 kDa
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NCBI Accession
- NP_055958
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Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
Target
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