PRKG1 Protein (His tag)

Catalog No. ABIN7318303

Product Details

Target: PRKG1 (Protein Kinase, CGMP-Dependent, Type I (PRKG1))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This PRKG1 protein is labelled with His tag.

Purpose: Recombinant Human PRKG1 Protein (His Tag)

Sequence: Gly2-Pro686

Characteristics: Recombinant Human cGMP-Dependent Protein Kinase 1 is produced by our Mammalian expression system and the target gene encoding Gly2-Pro686 is expressed with a 6His tag at the C-terminus.

Purity: > 80 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl,0.25 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF,20 % glycerol, pH 8.0.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: PRKG1 (Protein Kinase, CGMP-Dependent, Type I (PRKG1))

Alternative Name: PRKG1 (PRKG1 Products)

Background:

Background: cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one protein kinase domain. PRKG1 is mainly expressed in the lung and placenta. PRKG1 acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. PRKG1 can phosphorylate many proteins that regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm, and nociception.

Synonym: cGMP-Dependent Protein Kinase 1, cGK 1, cGK1, cGMP-Dependent Protein Kinase I, cGKI, PRKG1, PRKG1B, PRKGR1A, PRKGR1B

Molecular Weight: 78.8 kDa