SERPINA12 Protein (His tag)
Quick Overview for SERPINA12 Protein (His tag) (ABIN7319468)
Target
See all SERPINA12 ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This SERPINA12 protein is labelled with His tag.
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Purpose
- Recombinant Human Vaspin/SerpinA12 Protein (His Tag)
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Sequence
- Leu21-Lys414
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Characteristics
- Recombinant Human Serpin A12 is produced by our Mammalian expression system and the target gene encoding Leu21-Lys414 is expressed with a 10His tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 12 (SERPINA12) (AA 1-414) protein (GST tag)
SERPINA12 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 12 (SERPINA12) (AA 21-414) protein (His tag)SERPINA12 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 7.5.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- SERPINA12 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 12 (SERPINA12))
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Alternative Name
- Vaspin/SerpinA12
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Background
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Background: Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin has three β-sheets, nine α-helices, and one central loop, the structure is part of the set of distinctive features that are descriptive of Serpin family members. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that Vaspin mRNA expression in visceral fat is positively correlated with BMI and percent of body fat. and could be associated with parameters of obesity, insulin resistance, and glucose metabolism. These findings suggest a potential clinical use for Vaspin in ameliorating certain aberrations seen in the obesity metabolic syndrome.
Synonym: Serpin A12, OL-64, Visceral adipose tissue-derived serine protease inhibitor, Vaspin, Visceral adipose-specific serpin, SERPINA12
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Molecular Weight
- 46.5 kDa
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UniProt
- Q8IW75
Target
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