Stanniocalcin 1 Protein (STC1) (His tag)

Catalog No. ABIN7319806

Recombinant Stanniocalcin 1 protein expressed in Human Cells.

Quick Overview for Stanniocalcin 1 Protein (STC1) (His tag) (ABIN7319806)

Target: Stanniocalcin 1 (STC1)

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: >95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This Stanniocalcin 1 protein is labelled with His tag.

Purpose: Recombinant Human Stanniocalcin 1/STC-1 (C-6His)

Sequence: Thr18-Ala247

Characteristics: Recombinant Human Stanniocalcin 1 is produced by our Mammalian expression system and the target gene encoding Thr18-Ala247 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Stanniocalcin 1 (STC1)

Alternative Name: Stanniocalcin 1/STC-1

Background:

Background: Stanniocalcin 1 (STC-1) is a homodimeric glycoprotein hormone that is involved in calcium and phosphate homeostasis. It was originally identified in bony fishes, where elevation of calcium in serum causes the release of STC from the endocrine glands called the corpuscles of Stannius. STC-1 inhibits the breakdown of PAPP-A, protects cancer cells from apoptosis, reduces tumor size of liver cancers, promotes osteoblast differentiation and inhibits longitudinal bone growth directly at the growth plate. It is also a biomarker of brain and lung cancer progression. STC1 signals through inhibitory G-protein modulates CGRP receptor spatial localization during osteoblastogenesis and may function as a regulatory factor interacting with calcitonin peptide members during bone formation.

Synonym: Stanniocalcin 1, stanniocalcin-1, STC1, STC-1, STCSTC-1

Molecular Weight: 26.9 kDa

UniProt: P52823

Pathways: Hormone Activity