SULT1B1 Protein (His tag)

Catalog No. ABIN7317530

Recombinant SULT1B1 protein expressed in Escherichia coli (E. coli).

Quick Overview for SULT1B1 Protein (His tag) (ABIN7317530)

Target: SULT1B1 (Sulfotransferase Family 1B Member 1 (SULT1B1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This SULT1B1 protein is labelled with His tag.

Purpose: Recombinant Human SULT1B1 Protein (His Tag)(Active)

Sequence: Leu 2-Ile 296

Characteristics: A DNA sequence encoding the human SULT1B1 (NP_055280.2) (Leu 2-Ile 296) was expressed, with a N-terminal polyhistidine tag.

Biological Activity Comment: Measured by its ability to transfer sulfate from PAPS to 1-Napthol.The specific activity is > 40 pmoles/min/μg.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 0.1 M NaCl, 10 % glycerol, 1 mM DTT, pH 8.0

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SULT1B1 (Sulfotransferase Family 1B Member 1 (SULT1B1))

Alternative Name: SULT1B1

Background:

Background: Sulfotransferase family cytosolic 1B member 1; also known as Sulfotransferase 1B1; Sulfotransferase 1B2; Thyroid hormone sulfotransferase; SULT1B1 and ST1B2; is a cytoplasm protein which belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones; neurotransmitters; drugs; and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. SULT1B1 is highly expressed in the liver; peripheral blood leukocytes; colon (mucosal lining); small intestine (jejunum) and spleen. A lesser expression of SULT1B1 was observed in the lung; placenta and thymus. SULT1B1 catalyzes the sulfate conjugation of many hormones; neurotransmitters; drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds; and therefore their renal excretion; but it can also result in bioactivation to form active metabolites. SULT1B1 sulfates dopamine; small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones; including 3;3'-diiodothyronine; triidothyronine; reverse triiodothyronine and thyroxine.

Synonym: Sulfotransferase Family Cytosolic 1B Member 1; ST1B1; Sulfotransferase 1B1; Sulfotransferase 1B2; ST1B2; Thyroid Hormone Sulfotransferase; SULT1B1; ST1B2; SULT1B2

Molecular Weight: 35.7 kDa

NCBI Accession: NP_055280