TXNDC17 Protein
Quick Overview for TXNDC17 Protein (ABIN7198224)
Target
See all TXNDC17 ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human TXNDC17/TRP14/TXNL5 Protein
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Sequence
- Met 1-Asp 123
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Characteristics
- A DNA sequence encoding the mature form of human TXNDC17 (Q9BRA2) (Met 1-Asp 123) was expressed and purified, with an initial Met.
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Thioredoxin Domain Containing 17 (TXNDC17) (AA 2-123) protein (His tag)
TXNDC17 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses ELISA, WB
Thioredoxin Domain Containing 17 (TXNDC17) (AA 1-123), (full length) protein (GST tag)TXNDC17 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Thioredoxin Domain Containing 17 (TXNDC17) protein (Myc-DYKDDDDK Tag)TXNDC17 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile PBS, pH 7.4
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- TXNDC17 (Thioredoxin Domain Containing 17 (TXNDC17))
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Alternative Name
- TXNDC17//TXNL5
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Background
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Background: Cell surface A33 antigen, also known as glycoprotein A33, is a single-pass type I membrane protein which is expressed in normal gastrointestinal epithelium and in 95% of colon cancers. GPA33 contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. Intracellular traffic and recycling to the cell surface appear to play a major role in GPA33 function and to have an influence on its surface density superseding translational regulation. GPA33 has become a promising target of immunologic therapy strategies, but its biologic function and potential role in tumorigenesis are unknown. EpCAM protein and GPA33 mRNA expressions are specific and sensitive markers of Barrett's metaplasia (BM). GPA33 may also play a role in cell-cell recognition and signaling.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: TRP14;TXNL5
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Molecular Weight
- 13.9 kDa
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UniProt
- Q9BRA2
Target
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