Thrombomodulin Protein (THBD) (His tag)

Catalog No. ABIN7319438

This Recombinant Thrombomodulin protein is produced in Human Cells.

Quick Overview for Thrombomodulin Protein (THBD) (His tag) (ABIN7319438)

Target: Thrombomodulin (THBD)

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This Thrombomodulin protein is labelled with His tag.

Purpose: Recombinant Human Thrombomodulin/CD141 Protein (His Tag)

Sequence: Ala19-Ser515

Characteristics: Recombinant Human Thrombomodulin is produced by our Mammalian expression system and the target gene encoding Ala19-Ser515 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 8.0.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: Thrombomodulin (THBD)

Alternative Name: Thrombomodulin/CD141

Background:

Background: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Human Thrombomodulin/THBD predicts a signal peptide and a mature chain that consists of following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Predominantly synthesized by vascular endothelial cells, THBD inhibits coagulation and fibrinolysis. THBD gene polymorphisims are associated with human disease and THBD plays a role in thrombosis, stroke, arteriosclerosis, and cancer. For example, increased serum levels of THBD, due to protease cleavage, have been associated with smoking, cardiac surgery, atherosclerosis, liver cirrhosis, diabetes mellitus, cerebral and myocardial infarction, and multiple sclerosis.

Synonym: Thrombomodulin, THBD, TM, Fetomodulin, CD141, THRM

Molecular Weight: 52.9 kDa

UniProt: P07204