Quick Overview for TLK2 Protein (ABIN7317071)
Target
See all TLK2 ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human TLK2/PKU-ALPHA Protein
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Sequence
- Leu 397-Asn772
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Characteristics
- A DNA sequence encoding the human TLK2 (Q86UE8-1) (Leu397-Asn772) was fused with two additional amino acids (Gly & Pro) at the N-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Tousled-Like Kinase 2 (TLK2) (AA 1-718) protein (His tag)
custom-made TLK2 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Tousled-Like Kinase 2 (TLK2) (AA 1-772) protein (His tag)custom-made TLK2 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Tousled-Like Kinase 2 (TLK2) protein (GST tag,His tag)TLK2 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Tousled-Like Kinase 2 (TLK2) (Transcript Variant A) protein (Myc-DYKDDDDK Tag)TLK2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as sterile 20 mM Tris, 500 mM NaCl, 3 mM DTT, 10 % glycerol, pH 8.0
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- TLK2 (Tousled-Like Kinase 2 (TLK2))
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Alternative Name
- TLK2/PKU-ALPHA
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Background
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Background: Serine / threonine-protein kinase tousled-like 2; also known as PKU-alpha; Tousled-like kinase 2 and TLK2; is a nucleus protein which belongs to the protein kinase superfamily and Ser/Thr protein kinase family. The tousled-like kinases are an evolutionarily conserved family of proteins implicated in DNA repair; DNA replication and mitosis in metazoans and plants. Their absence from the yeasts and other eukaryotic 'microbes' suggests a specific role for them in the development of multicellular organisms. Tousled-like kinase 2 / TLK2 is widely expressed. It is present in fetal placenta; liver; kidney; pancreas; heart and skeletal muscle. It is also found in adult cell lines. Tousled-like kinase 2 / TLK2 contains one protein kinase domain. Tousled-like kinase 2 / TLK2 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.
Synonym: HsHPK;PKU-ALPHA
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Molecular Weight
- 43.6 kDa
Target
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