TPM3 Protein

Catalog No. ABIN7319117

Recombinant TPM3 protein expressed in Escherichia coli (E. coli).

Quick Overview for TPM3 Protein (ABIN7319117)

Target: TPM3 (Tropomyosin 3 (TPM3))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 90 % as determined by reducing SDS-PAGE.

Product Details

Purpose: Recombinant Human Tropomyosin α-3 Chain/TPM3 Protein

Sequence: Met 1-Met248

Characteristics: Recombinant Human Tropomyosin alpha-3 Chain is produced by our E.coli expression system and the target gene encoding Met1-Met248 is expressed.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: TPM3 (Tropomyosin 3 (TPM3))

Alternative Name: Tropomyosin alpha-3 Chain/TPM3

Background:

Background: Tropomyosin Alpha-3 Chain (TPM3) is a member of the Tropomyosin family. TPM3 exists as a heterodimer consisting of an alpha and a beta chain. TPM3 plays a central role in association with the Troponin complex and in the calcium dependent regulation of vertebrate striated muscle contraction. Defects in TPM3 are the cause of thyroid papillary carcinoma. Mutations in the TPM3 gene cause autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are linked with cancer.

Synonym: Tropomyosin Alpha-3 Chain, Gamma-Tropomyosin, Tropomyosin-3, Tropomyosin-5, hTM5, TPM3

Molecular Weight: 29.0 kDa