ANGPTL4 Protein (His tag)

Catalog No. ABIN7319763

This Recombinant ANGPTL4 protein is expressed in Human Cells.

Quick Overview for ANGPTL4 Protein (His tag) (ABIN7319763)

Target: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: >95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This ANGPTL4 protein is labelled with His tag.

Purpose: Recombinant Human Angiopoietin-Related Protein 4/ANGPTL4 (N-6His)

Sequence: Pro166-Ser406

Characteristics: Recombinant Human Angiopoietin Like Protein 4 is produced by our Mammalian expression system and the target gene encoding Pro166-Ser406 is expressed with a 6His tag at the N-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Comment:

32-38 kDa

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Alternative Name: Angiopoietin-Related protein 4

Background:

Background: Angiopoietin-related protein 4(ANGPTL4)is a secreted protein and contains 1 fibrinogen C-terminal domain. The protein may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

Synonym: Angiopoietin-related protein 4, 425O18-1, Angiopoietin-like protein 4, Fasting-induced adipose factor, Hepatic fibrinogen/angiopoietin-related protein, HFARP, Secreted protein Bk89, Angptl4, Farp, Fiaf, Ng27

Molecular Weight: 27.9 kDa

UniProt: Q9BY76

Pathways: Regulation of Lipid Metabolism by PPARalpha