IgG2 Fc protein (Fc Tag)
In vivo Grade
Origin: Human
Host: Mammalian Cells
Recombinant
> 95 %
in vivo, IsoC
-
- Target
- IgG2 Fc
- Protein Type
- Recombinant
- Origin
- Human
- Source
- Mammalian Cells
- Purification tag / Conjugate
- Fc Tag
- Application
- In vivo Studies (in vivo), Isotype Control (IsoC)
- Purpose
- In Vivo Grade Recombinant Human IgG2 Fc Protein
- Characteristics
- Human Fc (IgG2) is the tail region of an immunoglobulin G2 (IgG2) that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. The ~230 amino acid fragment generally exists as a dimer, although under reducing conditions, it exists as a monomer. It is the basis of prolonged pharmacokinetics of antibodies and is commonly used as a fusion to extend half-life of fusion proteins. IgG2 has a shorter hinge than IgG1, with 12 amino acid residues and four disulfide bridges at the Fab base. The hinge region of IgG2 also lacks a glycine residue, which along with its shortness almost completely prevents rotation and restricts lateral movement of the Fabs.
- Purity
- > 95 %
- Sterility
- Sterile filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg)
- Grade
- In vivo Grade
-
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
- Storage Comment
- 1 month from date of receipt, 2 to 8°C as supplied. 3 months from date of receipt, -20°C to -70°C as supplied.
- Expiry Date
- 3 months
-
- Target
- IgG2 Fc
-
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