Epiregulin Protein (EREG) (AA 63-108) (Fc Tag)
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- Target See all Epiregulin (EREG) Proteins
- Epiregulin (EREG)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 63-108
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Epiregulin protein is labelled with Fc Tag.
- Purpose
- Human EREG Protein
- Sequence
- Val63-Leu108
- Characteristics
- Recombinant Human EREG Protein is expressed from HEK293 with hFc tag at the N-Terminus.It contains Val63-Leu108.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product EREG Protein
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Epiregulin (EREG) (AA 56-101) protein (Fc Tag)
EREG Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Epiregulin (EREG) (AA 60-108) protein (His-IF2DI Tag)EREG Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Epiregulin (EREG) (AA 1-169) protein (GST tag)EREG Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22 μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Epiregulin (EREG)
- Alternative Name
- EREG (EREG Products)
- Background
- Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways.EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. As a consequence, EREG or EPGN induce less stable EGFR dimers than EGF-making them partial agonists of EGFR dimerization. Unexpectedly, this weakened dimerization elicits more sustained EGFR signaling than seen with EGF, provoking responses in breast cancer cells associated with differentiation rather than proliferation.
- Molecular Weight
- 32.6 kDa. Due to glycosylation, the protein migrates to 37-42 kDa based on Tris-Bis PAGE result.
- UniProt
- O14944
- Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
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