IFNA1 Protein (AA 24-189) (Fc Tag)
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- Target See all IFNA1 Proteins
- IFNA1 (Interferon, alpha 1 (IFNA1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 24-189
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IFNA1 protein is labelled with Fc Tag.
- Purpose
- Human IFN alpha 1 Protein
- Sequence
- Cys24-Glu189
- Characteristics
- Recombinant Human IFN alpha 1 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Cys24-Glu189.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- The affinity constant of 0.12 μM as determined in SPR assay (Biacore T200). See testing image for detail.
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Interferon, alpha 1 (IFNA1) (Active) protein
IFNA1 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Interferon, alpha 1 (IFNA1) (AA 24-189) protein (Fc Tag)IFNA1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Interferon, alpha 1 (IFNA1) (AA 1-189) protein (GST tag)IFNA1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Interferon, alpha 1 (IFNA1) (AA 24-133) protein (GST tag)IFNA1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Interferon, alpha 1 (IFNA1) (AA 24-189) protein (His tag)Crystallography grade IFNA1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
Interferon, alpha 1 (IFNA1) (AA 24-189) protein (His tag)Crystallography grade IFNA1 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- IFNA1 (Interferon, alpha 1 (IFNA1))
- Alternative Name
- IFN alpha 1 (IFNA1 Products)
- Synonyms
- IFL Protein, IFN Protein, IFN-ALPHA Protein, IFN-alphaD Protein, IFNA13 Protein, IFNA@ Protein, Ifa1 Protein, IFN-ALPHA-1 Protein, IFN1@ Protein, IFNA1 Protein, IFN-alpha Protein, IFN-gamma Protein, IFNA Protein, IFNA2 Protein, IFNA6 Protein, IFN-alpha1 Protein, interferon alpha 13 Protein, interferon alpha 1 Protein, interferon, alpha 1 Protein, interferon, alpha 13 Protein, interferon Protein, interferon-alpha 1 Protein, interferon, alpha, leukocyte Protein, interferon-alpha-14 Protein, IFNA13 Protein, IFNA1 Protein, Ifna1 Protein, ifna1 Protein, IFNA3 Protein, IFN-ALPHA-14 Protein
- Background
- IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes.
- Molecular Weight
- 46.14 kDa. Due to glycosylation, the protein migrates to 48-55 kDa based on Tris-Bis PAGE result.
- UniProt
- P01562
- Pathways
- JAK-STAT Signaling, Hepatitis C
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