IL1RAP Protein (AA 21-367) (His tag)

Catalog No. ABIN7274911

This Recombinant IL1RAP protein is expressed in HEK-293 Cells.

Quick Overview for IL1RAP Protein (AA 21-367) (His tag) (ABIN7274911)

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Product Details

Protein Characteristics: AA 21-367

Purification tag / Conjugate: This IL1RAP protein is labelled with His tag.

Purpose: Mouse IL-1R3/IL-1 RAcP Protein

Sequence: Ser21-Thr367

Characteristics: Recombinant Mouse IL-1R3/IL-1 RAcP Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser21-Thr367.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Alternative Name: IL-1R3

Background: Interleukin (IL)-1R3 is the co-receptor in three signaling pathways that involve six cytokines of the IL-1 family (IL-1α, IL-1β, IL-33, IL-36α, IL-36β and IL-36γ). In many diseases, multiple cytokines contribute to disease pathogenesis. For example, in asthma, both IL-33 and IL-1 are of major importance, as are IL-36 and IL-1 in psoriasis.

Molecular Weight: 41.1 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.

UniProt: Q61730-1

Pathways: NF-kappaB Signaling, Growth Factor Binding