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IL18BP Protein (AA 29-193) (Fc Tag)

IL18BP Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Catalog No. ABIN7274983
  • Target See all IL18BP Proteins
    IL18BP (Interleukin 18 Binding Protein (IL18BP))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 29-193
    Origin
    • 13
    • 4
    • 3
    • 2
    • 1
    Mouse
    Source
    • 10
    • 8
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This IL18BP protein is labelled with Fc Tag.
    Purpose
    Mouse IL-18BP Protein
    Sequence
    Thr29-Ala193
    Characteristics
    Recombinant Mouse IL-18BP Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Thr29-Ala193.
    Purity
    > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 1EU per μg by the LAL method.
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    Discover our top product IL18BP Protein
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  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
    Buffer
    Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
    Storage
    -20 °C,-80 °C
    Storage Comment
    -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    IL18BP (Interleukin 18 Binding Protein (IL18BP))
    Alternative Name
    IL-18BP (IL18BP Products)
    Background
    Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.
    Molecular Weight
    44.7 kDa. Due to glycosylation, the protein migrates to 60-75 kDa based on Tris-Bis PAGE result.
    UniProt
    Q9Z0M9
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