Klotho beta Protein (KLB) (AA 53-994) (His tag)

Catalog No. ABIN7275093

This Recombinant Klotho beta protein is produced in HEK-293 Cells.

Quick Overview for Klotho beta Protein (KLB) (AA 53-994) (His tag) (ABIN7275093)

Target: Klotho beta (KLB)

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC

Product Details

Protein Characteristics: AA 53-994

Purification tag / Conjugate: This Klotho beta protein is labelled with His tag.

Purpose: Mouse Beta Klotho Protein

Sequence: Phe53-Pro994

Characteristics: Recombinant Mouse Beta Klotho Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe53-Pro994.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as 0.22μm filtered solution in PBS ( pH 7.4).

Storage: -80 °C

Storage Comment: Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Klotho beta (KLB)

Alternative Name: Beta Klotho

Background: Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites.

Molecular Weight: 109.91 kDa. Due to glycosylation, the protein migrates to 120-130 kDa based on Tris-Bis PAGE result.

UniProt: Q99N32-1

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Growth Factor Binding