Layilin Protein (LAYN) (AA 22-235) (His tag)

Catalog No. ABIN7275132

Product Details

Target: Layilin (LAYN)

Protein Type: Recombinant

Protein Characteristics: AA 22-235

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Layilin protein is labelled with His tag.

Purpose: Human LAYN Protein

Sequence: Ala22-Leu235

Characteristics: Recombinant Human LAYN Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala22-Leu235.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Layilin (LAYN)

Alternative Name: LAYN (LAYN Products)

Background: Layilin (LAYN) is a critical gene that regulates T cell function. LAYN is correlated with prognosis and immune infiltrating levels of, including those of CD8 T cells, CD4 T cells, macrophages, neutrophils, and DCs in multiple cancers, especially in colon and gastric cancer patients. In addition, LAYN expression potentially contributes to regulation of tumor-associated macrophages (TAMs), DCs, T cell exhaustion and Tregs in colon and gastric cancer.

Molecular Weight: 25.4 kDa. Due to glycosylation, the protein migrates to 35-42 kDa based on Tris-Bis PAGE result.