Macrophage Scavenger Receptor 1 Protein (MSR1) (AA 77-451) (His tag)

Catalog No. ABIN7275296

Recombinant Macrophage Scavenger Receptor 1 protein expressed in HEK-293 Cells.

Quick Overview for Macrophage Scavenger Receptor 1 Protein (MSR1) (AA 77-451) (His tag) (ABIN7275296)

Target: Macrophage Scavenger Receptor 1 (MSR1)

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Product Details

Protein Characteristics: AA 77-451

Purification tag / Conjugate: This Macrophage Scavenger Receptor 1 protein is labelled with His tag.

Purpose: Human MSR1 Protein

Sequence: Lys77-Leu451

Characteristics: Recombinant Human MSR1 Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Lys77-Leu451.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Macrophage Scavenger Receptor 1 (MSR1)

Alternative Name: MSR1

Background: The macrophage scavenger receptor 1 (Msr1, also called SRA) is a pattern recognition receptor primarily expressed on myeloid cells, which plays an important role in the maintenance of immune homeostasis. Msr1 promotes the pathogenesis of virus-induced FH by enhancing induction of neutrophil NETosis and subsequent complement activation. Targeting Msr1 may be employed as a new immunotherapeutic strategy for FH.

Molecular Weight: 42.39 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.

UniProt: P21757-1