JAG1 Protein (AA 34-1046) (His tag)
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- Target See all JAG1 Proteins
- JAG1 (Jagged 1 (JAG1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 34-1046
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This JAG1 protein is labelled with His tag.
- Purpose
- Human Jagged 1/JAG1 Protein
- Sequence
- Gln34-Ser1046
- Characteristics
- Recombinant Human Jagged 1/JAG1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln34-Ser1046.
- Purity
- > 95 % as determined by Tris-Bis PAGE
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22 μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- JAG1 (Jagged 1 (JAG1))
- Alternative Name
- Jagged 1 (JAG1 Products)
- Background
- JAGGED1 (JAG1) is composed of a relatively small intracellular domain, a transmembrane domain and a larger extracellular component. JAG1 is widely expressed throughout mammalian development, across many tissues and developmental stages. The Notch signaling pathway and JAG1 in particular have been implicated in multiple forms of cancer and multiple aspects of cancer biology including tumor angiogenesis, neoplastic cell growth, cancer stem cell maintenance and the metastatic process.
- Molecular Weight
- 111.56 kDa. Due to glycosylation, the protein migrates to 120-140 kDa based on Tris-Bis PAGE result.
- Pathways
- Notch Signaling, Stem Cell Maintenance
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