CXCR3 Protein (AA 1-53) (mFc Tag)
Quick Overview for CXCR3 Protein (AA 1-53) (mFc Tag) (ABIN7491147)
Target
See all CXCR3 ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 1-53
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Purification tag / Conjugate
- This CXCR3 protein is labelled with mFc Tag.
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Purpose
- Recombinant human CXCR3 protein with C-terminal mouse Fc tag
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Specificity
- CXCR3 (Met1-Arg53) mFc (Pro99-Lys330)
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Characteristics
- Extracellular Domain Protein
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Purification
- Purified from cell culture supernatant by affinity chromatography
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))
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Alternative Name
- CXCR3
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Background
- This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
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Molecular Weight
- predicted molecular mass of 32.1 kDa after removal of the signal peptide. The apparent molecular mass of CXCR3-mFc is 25-55 kDa due to glycosylation.
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UniProt
- P49682
Target
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