BMPR1A Protein (AA 24-152) (Fc Tag)

Catalog No. ABIN7491355

This Recombinant BMPR1A protein is expressed in HEK-293 Cells.

Quick Overview for BMPR1A Protein (AA 24-152) (Fc Tag) (ABIN7491355)

Target: BMPR1A (Bone Morphogenetic Protein Receptor 1A (BMPR1A))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 24-152

Purification tag / Conjugate: This BMPR1A protein is labelled with Fc Tag.

Purpose: Recombinant Human BMPR1A Protein with C-terminal human Fc tag

Specificity: BMPR1A (Gln24-Arg152) hFc (Glu99-Ala330)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: BMPR1A (Bone Morphogenetic Protein Receptor 1A (BMPR1A))

Alternative Name: BMPR1A

Background: The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

Molecular Weight: predicted molecular mass of 40.3 kDa after removal of the signal peptide. The apparent molecular mass of BMPR1A-hFc is 35-70 kDa due to glycosylation.

UniProt: P36894

Pathways: Stem Cell Maintenance