Prostaglandin D2 Receptor 2 (PTGDR2) Protein

Catalog No. ABIN7491717

Synthetic Nanodisc protein expressed in HEK-293 Cells.

Quick Overview for Prostaglandin D2 Receptor 2 (PTGDR2) Protein (ABIN7491717)

Target: Prostaglandin D2 Receptor 2 (PTGDR2)

Protein Type: Synthetic Nanodisc

Origin: Human

Source: HEK-293 Cells

Product Details

Purpose: Human PTGDR2 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: Prostaglandin D2 Receptor 2 (PTGDR2)

Alternative Name: PTGDR2

Background: The protein is a G-protein-coupled receptor that is preferentially expressed in CD4 effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.

Molecular Weight: The human full length PTGDR2 protein has a MW of 43.3 kDa

UniProt: Q9Y5Y4

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling