LTA Protein (His tag)

Catalog No. ABIN7488960

This Recombinant LTA protein is expressed in HEK-293 Cells.

Quick Overview for LTA Protein (His tag) (ABIN7488960)

Target: LTA (Lymphotoxin-alpha (LTA))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: 90 %

Grade: MALS verified

Product Details

Purification tag / Conjugate: This LTA protein is labelled with His tag.

Purpose: Human TNF-beta / Lymphotoxin-alpha Protein, His Tag (MALS verified)

Sequence: Leu 35 - Leu 205

Characteristics: Human TNF-beta Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Leu 35 - Leu 205 (Accession # P01374).

Endotoxin Level: 1.0 EU per μg

Application Details

Comment:

This protein carries a polyhistidine tag at the C-terminus. (10xHis) The protein has a calculated MW of 20.5 kDa. The protein migrates as 26-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -20 °C

Storage Comment: -20°C

Target Details

Target: LTA (Lymphotoxin-alpha (LTA))

Alternative Name: TNF-beta

Target Type: Chemical

Background: The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene.

Molecular Weight: 20.5 kDa

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process