Claudin 1 Protein (CLDN1) (AA 29-115) (His tag)
Quick Overview for Claudin 1 Protein (CLDN1) (AA 29-115) (His tag) (ABIN7505011)
Target
See all Claudin 1 (CLDN1) ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 29-115
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Purification tag / Conjugate
- This Claudin 1 protein is labelled with His tag.
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Sequence
- Gln29-Lys115
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Characteristics
- A DNA sequence encoding theHuman CLDN1 protein (O95832) (Gln29-Lys115) was expressed with a N-His.
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Claudin 1 (CLDN1) (AA 1-211) protein (His tag)
custom-made CLDN1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Claudin 1 (CLDN1) (AA 1-211) protein (His tag)custom-made CLDN1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Claudin 1 (CLDN1) (AA 1-211) protein (GST tag)CLDN1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Claudin 1 (CLDN1) protein (Myc-DYKDDDDK Tag)CLDN1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. -
Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Expiry Date
- 12 months
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- Claudin 1 (CLDN1)
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Alternative Name
- CLDN1
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Background
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Abbreviation: CLDN1
Target Synonym: Senescence-associated epithelial membrane protein
Background: Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.
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Molecular Weight
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Calculated MW: 9.6 kDa
Observed MW: 14 kDa
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UniProt
- O95832
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Pathways
- Cell-Cell Junction Organization, Hepatitis C
Target
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