PPM1A Protein (AA 2-382) (His tag)
Quick Overview for PPM1A Protein (AA 2-382) (His tag) (ABIN7505335)
Target
See all PPM1A ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 2-382
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Purification tag / Conjugate
- This PPM1A protein is labelled with His tag.
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Sequence
- Gly2-Trp382
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Characteristics
- A DNA sequence encoding the Human PPM1A protein (P35813) (Gly 2-Trp 382) was expressed with a N-His.
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Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) (AA 1-382) protein (GST tag)
PPM1A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) protein (His tag)PPM1A Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 98 % as determined by SDS-PAGE
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) (Transcript Variant 1) protein (His tag)PPM1A Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)PPM1A Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. -
Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Expiry Date
- 12 months
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- PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
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Alternative Name
- PPM1A
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Background
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Abbreviation: PPM1A
Target Synonym: Protein Phosphatase 1A,Protein Phosphatase 2C Isoform Alpha,PP2C-Alpha,Protein Phosphatase IA,PPM1A,PPPM1A,PP2C-ALPHA,PP2CA,PP2Calpha
Background: Protein Phosphatase 1A (PPM1A) is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1A has a broad specificity. PPM1A negatively regulates the activities of MAP kinases and MAP kinase kinases. Also, it negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. In addition, PPM1A can dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control.
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Molecular Weight
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Calculated MW: 41.8 kDa
Observed MW: 45 kDa
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UniProt
- P35813
Target
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