Ceruloplasmin Protein (AA 729-1061) (His tag)

Catalog No. ABIN7505385

Recombinant Ceruloplasmin protein expressed in Escherichia coli (E. coli).

Quick Overview for Ceruloplasmin Protein (AA 729-1061) (His tag) (ABIN7505385)

Target: Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))

Protein Type: Recombinant

Origin: Mouse

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 729-1061

Purification tag / Conjugate: This Ceruloplasmin protein is labelled with His tag.

Sequence: Tyr729-Gly1061

Characteristics: A DNA sequence encoding the Mouse CP protein (Q61147) (Tyr729-Gly1061) was expressed with a N-His .

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))

Alternative Name: Ceruloplasmin

Background:

Abbreviation: Ceruloplasmin,CP

Target Synonym: CERU_MOUSE,EC:1.16.3.1,Ferroxidase

Background: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.

Molecular Weight:

Calculated MW: 36.52 kDa

Observed MW: 40 kDa

UniProt: Q61147

Pathways: Transition Metal Ion Homeostasis