FGG Protein (AA 26-445) (His tag)

Catalog No. ABIN7505543

This Recombinant FGG protein is expressed in Escherichia coli (E. coli).

Quick Overview for FGG Protein (AA 26-445) (His tag) (ABIN7505543)

Target: FGG (Fibrinogen gamma Chain (FGG))

Protein Type: Recombinant

Origin: Rat

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 26-445

Purification tag / Conjugate: This FGG protein is labelled with His tag.

Sequence: Gln 26-Pro 445

Characteristics: A DNA sequence encoding the Rat FGG protein (P02680 ) (Gln 26-Pro 445) was expressed with N-His tag.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: FGG (Fibrinogen gamma Chain (FGG))

Alternative Name: FGG

Background:

Abbreviation: FGG,Fibrinogen gamma chain

Target Synonym: FIBG,Fibrinogen gamma chain,fibrinogen gamma-b chain

Background: Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Molecular Weight:

Calculated MW: 46.09 kDa

Observed MW: 60 kDa

UniProt: P02680