SCGB1A1 Protein (AA 22-91) (His tag)

Catalog No. ABIN7505615

This Recombinant SCGB1A1 protein is expressed in HEK-293 Cells.

Quick Overview for SCGB1A1 Protein (AA 22-91) (His tag) (ABIN7505615)

Target: SCGB1A1 (Secretoglobin, Family 1A, Member 1 (Uteroglobin) (SCGB1A1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 22-91

Purification tag / Conjugate: This SCGB1A1 protein is labelled with His tag.

Sequence: Glu22-Asn91

Characteristics: A DNA sequence encoding the Human CC16 protein (P11684) (Met 1-Asn 91) was expressed with a C-His.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: SCGB1A1 (Secretoglobin, Family 1A, Member 1 (Uteroglobin) (SCGB1A1))

Alternative Name: CC16

Background:

Abbreviation: Uteroglobin,SCGB1A1

Target Synonym: Uteroglobin,Clara cell phospholipid-binding protein,CCPBP,Clara cells 10 kDa secretory protein,CC10,Secretoglobin family 1A member 1,Urinary protein 1,UP-1,UP1,Urine protein 1,SCGB1A1,CCSP,UGB

Background: Uteroglobin is a small, non-glycosylated secreted protein of the secretoglobin superfamily. It is produced by the non-ciliated, non-mucous secretory cells that predominate in lung bronchioles (Clara cells), and other non-ciliated epithelia that communicate with the external environment. Expression is induced by steroid hormones such as estrogen, and enhanced by the non-steroid hormone prolactin. Human Uteroglobin cDNA encodes a 21 amino acid (aa) signal sequence and a 70 aa mature protein. The mature protein forms a disulfide-linked head-to-tail homodimer of 16 kDa. This homodimer is thought to form a binding pocket that binds hydrophobic ligands such as phospholipids, progesterone and retinols. Binding of fibronectin to Uteroglobin in the kidney is thought to protect against nephropathy, while binding of the lipocalin-1 receptor has been reported to suppress cancer cell motility and invasion.

Molecular Weight:

Calculated MW: 9.9 kDa

Observed MW: 10 kDa

UniProt: P11684