CD59 Protein (CD59) (AA 1-101) (His tag)

Catalog No. ABIN7505653

This Recombinant CD59 protein is produced in HEK-293 Cells.

Quick Overview for CD59 Protein (CD59) (AA 1-101) (His tag) (ABIN7505653)

Target: CD59

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 1-101

Purification tag / Conjugate: This CD59 protein is labelled with His tag.

Sequence: Met1-Glu101

Characteristics: A DNA sequence encoding the Human CD59 protein (P13987) (Met1-Glu101) was expressed with a C-His.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: CD59

Alternative Name: CD59

Background:

Abbreviation: CD59

Target Synonym: 16.3A5,1F5,1F5,EJ16,EJ30,EL32,FLJ38134,FLJ92039,G344,HRF 20,Ly 6

Background: CD59 glycoprotein, also known as 20 kDa homologous restriction factor, HRF20, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

Molecular Weight:

Calculated MW: 11 kDa

Observed MW: 15 kDa

UniProt: P13987

Pathways: Complement System