SCGB1A1 Protein (AA 1-96) (His tag)

Catalog No. ABIN7505754

Recombinant SCGB1A1 protein expressed in HEK-293 Cells.

Quick Overview for SCGB1A1 Protein (AA 1-96) (His tag) (ABIN7505754)

Target: SCGB1A1 (Secretoglobin, Family 1A, Member 1 (Uteroglobin) (SCGB1A1))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 1-96

Purification tag / Conjugate: This SCGB1A1 protein is labelled with His tag.

Sequence: Met 1-Phe 96

Characteristics: A DNA sequence encoding the Mouse CC17 protein (P11684) (Met 1-Phe 96) was expressed with a C-His.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: SCGB1A1 (Secretoglobin, Family 1A, Member 1 (Uteroglobin) (SCGB1A1))

Alternative Name: Uteroglobin

Background:

Abbreviation: Uteroglobin,SCGB1A1

Target Synonym: Uteroglobin,Clara cell 17 kDa protein,Clara cell phospholipid-binding protein,CCPBP,Clara cells 10 kDa secretory protein,CC10,PCB-binding protein,Secretoglobin family 1A member 1,Scgb1a1,Cc10,Ugb,CC16,CCSP,PCB-BP,UG,UGB,Utg

Background: Uteroglobin(UG, SCGB1A1) is the founding member of the secretoglobin family of small,secreted, disulfide-bridged dimeric proteins found only in mammals. This protein is mainly expressed in lung, with anti-inflammatory/immunomodulatory properties. CCAAT/enhancer-binding proteins(C/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression, whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with anti-inflammatory/immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A(2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its anti-inflammatory activities, Uteroglobin manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. Uteroglobin is a potential drug target. The mechanism of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.

Molecular Weight:

Calculated MW: 10.45 kDa

Observed MW: 10 kDa

UniProt: Q06318