CGRP Protein (AA 83-119) (Fc Tag)

Catalog No. ABIN7538155

Recombinant CGRP protein expressed in Mammalian Cells.

Quick Overview for CGRP Protein (AA 83-119) (Fc Tag) (ABIN7538155)

Target: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Protein Type: Recombinant

Origin: Mouse

Source: Mammalian Cells

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 83-119

Purification tag / Conjugate: This CGRP protein is labelled with Fc Tag.

Purpose: Recombinant mouse CGRP protein with C-terminal human Fc tag

Specificity: Mouse CGRP (Ser83-Phe119) hFc (Glu99-Ala330)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Alternative Name: CGRP

Background: This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide (CGRP) and katacalcin. Alternative splicing of the mRNA results in multiple variants that encode either calcitonin or CGRP preproproteins. Post-translational processing of the calcitonin and CGRP propeptides results in either calcitonin and katacalcin, or CGRP, respectively. Calcitonin and katacalcin modulate calcium levels in the blood stream. CGRP can function as a vasodilator and play a role in the transmission of pain. The human homolog of CGRP was found to have antimicrobial activity. [provided by RefSeq, Mar 2015]

Molecular Weight: predicted molecular mass of 29.9 kDa after removal of the signal peptide. The apparent molecular mass of mCGRP-hFc is 25-35 kDa due to glycosylation.

UniProt: Q99JA0

Pathways: Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour