SPRR2A Protein (AA 1-72) (Fc Tag)

Catalog No. ABIN7546277

Product Details

Target: SPRR2A (Small Proline Rich Protein 2A (SPRR2A))

Protein Type: Recombinant

Protein Characteristics: AA 1-72

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This SPRR2A protein is labelled with Fc Tag.

Purpose: Predefined custom protein recombinant SPRR2A Protein expressed in mammalian cells.

Sequence: MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC QQKYPPVTPS PPCQSKYPPK SK Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: SPRR2A (Small Proline Rich Protein 2A (SPRR2A))

Alternative Name: SPRR2A (SPRR2A Products)

Background: Small proline-rich protein 2A (SPR-2A) (2-1),FUNCTION: Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (PubMed:34735226). Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (By similarity). May also be involved in the development of the cornified envelope of squamous epithelia, however, additional evidences are required to confirm this result in vivo (PubMed:8325635). {ECO:0000250|UniProtKB:P0DV37, ECO:0000269|PubMed:34735226, ECO:0000269|PubMed:8325635}.

Molecular Weight: 8.0 kDa

UniProt: P35326

AlphaFold: P35326