PWWP2A Protein (AA 1-755) (His tag)
custom-made
PWWP2A
Origin: Human
Host: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- Target See all PWWP2A products
- PWWP2A (PWWP Domain Containing 2A (PWWP2A))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-755
- Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This PWWP2A protein is labelled with His tag.
- Purpose
- Predefined custom protein recombinant PWWP2A Protein expressed in mammalian cells.
- Sequence
- MAAVAAEAAA TAASPGEGGA GEAEPEMEPI PGSEAGTDPL PVTATEASVP DGETDGQQSA PQADEPPLPP PPPPPGELAR SPEAVGPELE AEEKLSVRVA ESAAAAPQGG PELPPSPASP PEQPPAPEER EEPPLPQPVA PALVPPAGGD STVSQLIPGS EVRVTLDHII EDALVVSFRF GEKLFSGVLM DLSKRFGPHG IPVTVFPKRE YKDKPEAMPL QSNTFQEGTE VKCEANGAVP DDPSPVPHPE LSLAESLWTS KPPPLFHEGA PYPPPLFIRD TYNQSIPQPP PRKIKRPKRK MYREEPTSIM NAIKLRPRQV LCDKCKNSVV AEKKEIRKGS SATDSSKYED KKRRNESVTT VNKKLKTDHK VDGKNQNESQ KRNAVVKVSN IAHSRGRVVK VSAQANTSKA QLSTKKVLQS KNMDHAKARE VLKIAKEKAQ KKQNETSTSK NAHSKVHFTR RYQNPSSGSL PPRVRLKPQR YRNEENDSSL KTGLEKMRSG KMAPKPQSRC TSTRSAGEAP SENQSPSKGP EEASSEVQDT NEVHVPGDQD EPQTLGKKGS KNNISVYMTL NQKKSDSSSA SVCSIDSTDD LKSSNSECSS SESFDFPPGS MHAPSTSSTS SSSKEEKKLS NSLKMKVFSK NVSKCVTPDG RTICVGDIVW AKIYGFPWWP ARILTITVSR KDNGLLVRQE ARISWFGSPT TSFLALSQLS PFLENFQSRF NKKRKGLYRK AITEAAKAAK QLTPEVRALL TQFET Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.
- Specificity
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
- Characteristics
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Key Benefits:
- Predefined custom protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified. - Purity
- > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
- Grade
- custom-made
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PWWP Domain Containing 2A (PWWP2A) (AA 1-730) protein (His tag)
custom-made PWWP2A Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- Application Notes
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- The buffer composition is at the discretion of the manufacturer.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C.
- Expiry Date
- 12 months
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- Target
- PWWP2A (PWWP Domain Containing 2A (PWWP2A))
- Alternative Name
- PWWP2A (PWWP2A Products)
- Background
- PWWP domain-containing protein 2A,FUNCTION: Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:30327463). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260, PubMed:30327463). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (By similarity). Essential for proper mitosis progression (PubMed:28645917). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:28645917, ECO:0000269|PubMed:30228260, ECO:0000269|PubMed:30327463}.
- Molecular Weight
- 82.0 kDa
- UniProt
- Q96N64
- AlphaFold
- Q96N64
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