BEX2 Protein (AA 1-128) (His tag)
-
- Target See all BEX2 Proteins
- BEX2 (Brain Expressed X-Linked 2 (BEX2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-128
-
Origin
- Human
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This BEX2 protein is labelled with His tag.
- Purpose
- Made-to-order recombinant BEX2 Protein expressed in mammalian cells.
- Sequence
- MESKEERALN NLIVENVNQE NDEKDEKEQV ANKGEPLALP LNVSEYCVPR GNRRRFRVRQ PILQYRWDIM HRLGEPQARM REENMERIGE EVRQLMEKLR EKQLSHSLRA VSTDPPHHDH HDEFCLMP Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.
- Specificity
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
- Characteristics
-
Key Benefits:
- Made to order protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified. - Purity
- > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
- Grade
- custom-made
-
Brain Expressed X-Linked 2 (BEX2) (AA 1-129) protein (His tag)
custom-made BEX2 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Brain Expressed X-Linked 2 (BEX2) (AA 1-128) protein (His-IF2DI Tag)BEX2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses ELISA, WB
-
- Application Notes
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- The buffer composition is at the discretion of the manufacturer.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C.
- Expiry Date
- 12 months
-
- Target
- BEX2 (Brain Expressed X-Linked 2 (BEX2))
- Alternative Name
- BEX2 (BEX2 Products)
- Background
- Protein BEX2 (Brain-expressed X-linked protein 2) (hBex2),FUNCTION: Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer (PubMed:19711341). Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA (PubMed:19711341). Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A (PubMed:19711341). Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (PubMed:19711341). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). {ECO:0000250|UniProtKB:Q9WTZ8, ECO:0000269|PubMed:19711341}.
- Molecular Weight
- 15.3 kDa
- UniProt
- Q9BXY8
- AlphaFold
- Q9BXY8
-
