SNM1 Protein (AA 1-1040) (His tag)

Catalog No. ABIN7553625

Recombinant SNM1 protein expressed in HEK-293 Cells.

Quick Overview for SNM1 Protein (AA 1-1040) (His tag) (ABIN7553625)

Target: SNM1 (DCLRE1A) (DNA Cross-Link Repair 1A (DCLRE1A))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-1040

Purification tag / Conjugate: This SNM1 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant DCLRE1A Protein expressed in mammalian cells.

Sequence: MLEDISEEDI WEYKSKRKPK RVDPNNGSKN ILKSVEKATD GKYQSKRSRN RKRAAEAKEV KDHEVPLGNA GCQTSVASSQ NSSCGDGIQQ TQDKETTPGK LCRTQKSQHV SPKIRPVYDG YCPNCQMPFS SLIGQTPRWH VFECLDSPPR SETECPDGLL CTSTIPFHYK RYTHFLLAQS RAGDHPFSSP SPASGGSFSE TKSGVLCSLE ERWSSYQNQT DNSVSNDPLL MTQYFKKSPS LTEASEKIST HIQTSQQALQ FTDFVENDKL VGVALRLANN SEHINLPLPE NDFSDCEISY SPLQSDEDTH DIDEKPDDSQ EQLFFTESSK DGSLEEDDDS CGFFKKRHGP LLKDQDESCP KVNSFLTRDK YDEGLYRFNS LNDLSQPISQ NNESTLPYDL ACTGGDFVLF PPALAGKLAA SVHQATKAKP DEPEFHSAQS NKQKQVIEES SVYNQVSLPL VKSLMLKPFE SQVEGYLSSQ PTQNTIRKLS SENLNAKNNT NSACFCRKAL EGVPVGKATI LNTENLSSTP APKYLKILPS GLKYNARHPS TKVMKQMDIG VYFGLPPKRK EEKLLGESAL EGINLNPVPS PNQKRSSQCK RKAEKSLSDL EFDASTLHES QLSVELSSER SQRQKKRCRK SNSLQEGACQ KRSDHLINTE SEAVNLSKVK VFTKSAHGGL QRGNKKIPES SNVGGSRKKT CPFYKKIPGT GFTVDAFQYG VVEGCTAYFL THFHSDHYAG LSKHFTFPVY CSEITGNLLK NKLHVQEQYI HPLPLDTECI VNGVKVVLLD ANHCPGAVMI LFYLPNGTVI LHTGDFRADP SMERSLLADQ KVHMLYLDTT YCSPEYTFPS QQEVIRFAIN TAFEAVTLNP HALVVCGTYS IGKEKVFLAI ADVLGSKVGM SQEKYKTLQC LNIPEINSLI TTDMCSSLVH LLPMMQINFK GLQSHLKKCG GKYNQILAFR PTGWTHSNKF TRIADVIPQT KGNISIYGIP YSEHSSYLEM KRFVQWLKPQ KIIPTVNVGT WKSRSTMEKY FREWKLEAGY Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: SNM1 (DCLRE1A) (DNA Cross-Link Repair 1A (DCLRE1A))

Alternative Name: DCLRE1A

Background: DNA cross-link repair 1A protein (Beta-lactamase DCLRE1A) (EC 3.5.2.6) (SNM1 homolog A) (hSNM1) (hSNM1A),FUNCTION: May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986). {ECO:0000269|PubMed:15542852}.

Molecular Weight: 116.4 kDa

UniProt: Q6PJP8

AlphaFold: Q6PJP8