TRIM40 Protein (AA 1-246) (His tag)
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- Target See all TRIM40 Proteins
- TRIM40 (Tripartite Motif Containing 40 (TRIM40))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-246
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TRIM40 protein is labelled with His tag.
- Purpose
- Predefined custom protein recombinant Trim40 Protein expressed in mammalian cells.
- Sequence
- MGSLDKDNQD ICPICLDPLK EAVSTDCRHL FCRMCLTQHM DKASVSGILS CPVCRKPCSE GVLGDNYICH THQKRVRRFC EASGHLLCEE CLQSPEHQSH TELSIENAIS HYKERLNRRS RKLRKDLGNL QQLKAQEKKM LQALQVDCEC HRLRTDLQNQ DQTKEQLKAL PWHWLDQEDL PEEVAKIFSF SEAVTQLSIL VSGLERMAKD LDASTLKDAS DLLDRSAPQK LEGLLSRVSP AGPKLS Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.
- Specificity
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
- Characteristics
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Key Benefits:
- Predefined custom protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified. - Purity
- > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
- Grade
- custom-made
- Top Product
- Discover our top product TRIM40 Protein
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Tripartite Motif Containing 40 (TRIM40) (AA 1-258) protein (His tag)
custom-made TRIM40 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Tripartite Motif Containing 40 (TRIM40) (AA 1-258) protein (GST tag)TRIM40 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Tripartite Motif Containing 40 (TRIM40) protein (His tag)TRIM40 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- The buffer composition is at the discretion of the manufacturer.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C.
- Expiry Date
- 12 months
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- Target
- TRIM40 (Tripartite Motif Containing 40 (TRIM40))
- Alternative Name
- Trim40 (TRIM40 Products)
- Background
- E3 ubiquitin ligase TRIM40 (EC 2.3.2.27) (Probable E3 NEDD8-protein ligase),FUNCTION: E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response. Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation. Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation. {ECO:0000250|UniProtKB:Q6P9F5}.
- Molecular Weight
- 27.9 kDa
- UniProt
- Q3UWA4
- AlphaFold
- Q3UWA4
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