TRIM56 Protein (AA 1-734) (His tag)

Catalog No. ABIN7558360

This Recombinant TRIM56 protein is produced in HEK-293 Cells.

Quick Overview for TRIM56 Protein (AA 1-734) (His tag) (ABIN7558360)

Target: TRIM56 (Tripartite Motif Containing 56 (TRIM56))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-734

Purification tag / Conjugate: This TRIM56 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Trim56 Protein expressed in mammalian cells.

Sequence: MNSKVSSPTL LEALSSDFLA CKICLEQLHT PKTLPCLHTY CQDCLAQLDI GGQVRCPECR EIVPVPAEGV AAFKTNFFVN GLLDLVKARA PGDVHSGKPT CALCPLVGGK SSGGPATARC LDCADDLCQA CADGHRCSRQ THKHRVVDLV GYRAGWYDEE ARERQASQCP QHPGEALCFL CQPCSQLLCK DCRLGPHIDH PCLPLAEAVR SRKPGLEELL AGVDSNLVEL EATRVAEKEA LALLREQAAS VGTQVEEAAE RILKSLLAQK QEVLGQLRAL VEAAEEATRE RLTKIERQEQ VAKAAAAFAR RVLSLGLEAE ILSLEGAITQ RLRQLQDAPW TSGPTRCVLP QLELHPGLED KNCHLLRLIF EEPKQSPKDS GKGGAGTQGG DEAQGQGDDR TKIGKQGGAQ PLTPKEGKDQ NPQEDDGVFI ERGNRPNKKK KCKGRGKSVS REPSPILRPN LEGSGLLPRP VFSWSFPTRM PGDKRSPRIT GLCPYGPQEI LVADEQNRVL KRFSLNGDYK GTVQVPEGCS PCSVAALQNA VAFSANAKLY LVSPDGEIQW RRSLSLTQSS HAVAAMPCGD RVAVSVAGHV EVYKKDGSLA TRFIPGGKAS RGQRALVFLT TSPQGNFVGS DWQQNSVVFC DGLGQVIWEY KGPGLHGCQP GSVSVDKKGY IFLTLREVNK VVILDPKGSL LGDFLTAYHG LEKPRVTTMV DGKYLVVSLS NGTIHVFRVR FPDS Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: TRIM56 (Tripartite Motif Containing 56 (TRIM56))

Alternative Name: Trim56

Background: E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (Tripartite motif-containing protein 56),FUNCTION: E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21074459, PubMed:29426904). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (PubMed:21074459). Also mediates monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (PubMed:29426904). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling (By similarity). Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (By similarity). {ECO:0000250|UniProtKB:Q9BRZ2, ECO:0000269|PubMed:21074459, ECO:0000269|PubMed:29426904}.

Molecular Weight: 79.5 kDa

UniProt: Q80VI1

AlphaFold: Q80VI1