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GRAMD4 Protein (AA 1-633) (His tag)

custom-made GRAMD4 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Catalog No. ABIN7559224
  • Target See all GRAMD4 products
    GRAMD4 (GRAM Domain Containing 4 (GRAMD4))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 1-633
    Origin
    Mouse
    Source
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This GRAMD4 protein is labelled with His tag.
    Purpose
    Predefined custom protein recombinant Gramd4 Protein expressed in mammalian cells.
    Sequence
    MGIASHSAFR ERESSPTGAS LDASPRPWDK GLSGREPPRH VQVRPRSAVL NMLRRLDRIR FRGHKREDLL DLAESPNASD TECGDEIPLK TPRPSPRDSE ELRDPAGPGT LIMAAGVQDF NRTEFDRLNE IKGHLEIALL EKHFLQEELR KLREETNSEM LRQELDRERQ RRIELEQKMQ EVLKARSEEQ PAQPQQPPKG QSQASNGTGT ERRSQGLASR VQKWFYERFG EYIEDFRFQP EENTVETEEP LSARRLTENM RRLKRGAKPV TNFVKNLSAL SDWYSIYTSA IAFTVYMNAV WHGWAIPMFL FLAILRLSLN YLIARGWRIQ WSIVPEVSEA VEPAKEDLTV SEKFQLVLDV AQKAQNLFGK MADILEKIKN LFMWVQPETT QKLYVALWAA FLASCFFPYR LVGLAVGLYA GIKFFLIDFI FKRCPRLRAK YDTPYIIWRS LPTDPQLKER AGATVSRRLQ TASSRSYVSS APAGLSKDED AGRFHSTKKG NFHEIFNLTE NERPLAVCEN GWRCCLINRD RKMPTDYIRN GVLYVTENYL CFESSKSGSS KRNKVIKLMD ITDIQKYKVL SVLPGSGMGI AVSTPSTQKP LVFGAMVHRD EAFETIFSQY VKITSAAASG GDS Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.
    Specificity
    If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
    Characteristics
    Key Benefits:
    • Predefined custom protein - from design to production - by highly experienced protein experts.
    • Protein expressed in mammalian cells and purified in one-step affinity chromatography
    • The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
    • State-of-the-art algorithm used for plasmid design (Gene synthesis).
    This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

    If you are not interested in a full length protein, please contact us for individual protein fragments.

    The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.
    Purity
    > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
    Grade
    custom-made
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  • Application Notes
    We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    The buffer composition is at the discretion of the manufacturer.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C.
    Expiry Date
    12 months
  • Target
    GRAMD4 (GRAM Domain Containing 4 (GRAMD4))
    Alternative Name
    Gramd4 (GRAMD4 Products)
    Background
    GRAM domain-containing protein 4 (Death-inducing protein),FUNCTION: Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (By similarity). Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (PubMed:25917084). {ECO:0000250|UniProtKB:Q6IC98, ECO:0000269|PubMed:25917084}.
    Molecular Weight
    72.3 kDa
    UniProt
    Q8CB44
    AlphaFold
    Q8CB44
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