ITM2C Protein (AA 1-269) (His tag)

Catalog No. ABIN7559993

This Recombinant ITM2C protein is expressed in HEK-293 Cells.

Quick Overview for ITM2C Protein (AA 1-269) (His tag) (ABIN7559993)

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-269

Purification tag / Conjugate: This ITM2C protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Itm2c Protein expressed in mammalian cells.

Sequence: MVKISFQPAV AGIKADKADK AAASGPASAS APAAEILLTP AREERPPRHR SRKGGSVGGV CYLSMGMVVL LMGLVFASVY IYRYFFLAQL ARDNFFHCGV LYEDSLSSQI RTRLELEEDV KIYLEENYER INVPVPQFGG GDPADIIHDF QRGLTAYHDI SLDKCYVIEL NTTIVLPPRN FWELLMNVKR GTYLPQTYII QEEMVVTEHV RDKEALGSFI YHLCNGKDTY RLRRRSTRRR INKRGGKNCN AIRHFENTFV VETLICGVV Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Alternative Name: Itm2c

Background: Integral membrane protein 2C (Transmembrane protein BRI3) [Cleaved into: CT-BRI3],FUNCTION: Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. {ECO:0000269|PubMed:14592447}.

Molecular Weight: 30.5 kDa

UniProt: Q91VK4

AlphaFold: Q91VK4