FKBP6 Protein (AA 1-327) (His tag)

Catalog No. ABIN7560096

Product Details

Target: FKBP6 (FK506 Binding Protein 6, 36kDa (FKBP6))

Protein Type: Recombinant

Protein Characteristics: AA 1-327

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This FKBP6 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Fkbp6 Protein expressed in mammalian cells.

Sequence: MGGSTRDPGA LEGAGILGQS PYERLSQRML DISGDRGVLK DIIREGTGDT VTPDASVLVK YSGYLEHMDK PFDSNCFRKT PRLMKLGEDI TLWGMELGLL SMRKGELARF LFKPAYAYGT LGCPPLIPPN ATVLFEIELI DFLDSAESDK FCALSAEQQE QFPLQKVLKV AATEREFGNY LFRQNRFCDA KVRYKRALLL LHRRLATCEE QHLVEPAVLL VLLNLSFVYL KLDRPAMALR YGEQALLIDK RNAKALFRCG QACLLLTEYE RARDFLVRAQ KEQPCNHDIN NELKKLSSHY RDYVDREREM CHRMFAPCGS RSSVGGN Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: FKBP6 (FK506 Binding Protein 6, 36kDa (FKBP6))

Alternative Name: Fkbp6 (FKBP6 Products)

Background: Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36),FUNCTION: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes. {ECO:0000269|PubMed:12764197, ECO:0000269|PubMed:18408354, ECO:0000269|PubMed:22902560}.

Molecular Weight: 37.1 kDa

UniProt: Q91XW8

AlphaFold: Q91XW8

Pathways: M Phase