FLVCR Protein (AA 1-560) (His tag)

Catalog No. ABIN7562066

This Recombinant FLVCR protein is expressed in HEK-293 Cells.

Quick Overview for FLVCR Protein (AA 1-560) (His tag) (ABIN7562066)

Target: FLVCR (FLVCR1) (Feline Leukemia Virus Subgroup C Cellular Receptor 1 (FLVCR1))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-560

Purification tag / Conjugate: This FLVCR protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Flvcr1 Protein expressed in mammalian cells.

Sequence: MARPDDEVGP AVAPGHPLGK GYLPVPKGAP DGEARLVPQN GPEALNGGPG LGPLIAGAQG GPQALIAAEE ETQARLLPAG DGEDVPCPAC PPRTALSPRR FVVLLIFSLY SLVNAFQWIQ YSSISNVFED FYEVSPLHIN WLSMVYMVAY VPLIFPATWL LDTRGLRLTA LLGSGLNCLG AWVKCGSVQR HLFWVTMLGQ ILCSVAQVFI LGLPSPVASV WFGPKEVSTA CATAVLGNQL GTAVGFLLPP VLVPALGTQN STGLLAHTQN NTDLLAHNIN TMFYGTAFIS TFLFFLTIIA FKEKPPLPPS QAQAVLRDSP PEEYSYKSSI WNLCRNIPFV LLLVSYGIMT GAFYSISTLL NQIILTYYVG EEVNAGRIGL TLVVAGMVGS ILCGLWLDYT KTYKQTTLIV YVLSFIGMLI FTFTLNLGYI IVVFFTGGIL GFFMTGYLPL GFEFAVEITY PESEGMSSGL LNTAAQILGI FFTLAQGKIT TDYNSPEAGN IFLCAWMFVG IILTALIKSD LRRHNINTGL TNIDVKAVPV DSRVDPKPKV MVSIQSESSL Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: FLVCR (FLVCR1) (Feline Leukemia Virus Subgroup C Cellular Receptor 1 (FLVCR1))

Alternative Name: Flvcr1

Background: Heme transporter FLVCR1 (Feline leukemia virus subgroup C receptor-related protein 1) (Feline leukemia virus subgroup C receptor) (Major facilitator superfamily domain containing 7B) (Mfsd7b),FUNCTION: [Isoform 1]: Heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythropoiesis, a process in which heme synthesis intensifies. Possibly export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. The molecular mechanism of heme transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated. {ECO:0000250|UniProtKB:Q9Y5Y0, ECO:0000269|PubMed:18258918, ECO:0000269|PubMed:23187127}., FUNCTION: [Isoform 2]: Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation. {ECO:0000269|PubMed:23187127}.

Molecular Weight: 60.5 kDa

UniProt: B2RXV4

AlphaFold: B2RXV4

Pathways: Transition Metal Ion Homeostasis