Ataxin 2 Protein (ATXN2) (AA 1-1285) (His tag)

Catalog No. ABIN7562532

Recombinant Ataxin 2 protein expressed in HEK-293 Cells.

Quick Overview for Ataxin 2 Protein (ATXN2) (AA 1-1285) (His tag) (ABIN7562532)

Target: Ataxin 2 (ATXN2)

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-1285

Purification tag / Conjugate: This Ataxin 2 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Atxn2 Protein expressed in mammalian cells.

Sequence: MRSSTAAVQR PAAGDPEPRR PAGWAARRSL PRTARRGGRG GAVAYPSAGP PPRGPGAPPR GPRSPPCASD CFGSNGHGAS RPGSRRLLGV CGPPRPFVVV LLALAPAATP ARACPPGVRA SPPRSGVSSS ARPAPGCPRP ACEPVYGPLT MSLKPQPQPP APATGRKPGG GLLSSPGAAP ASAAVTSASV VPAPAAPVAS SSAAAGGGRP GLGRGRNSSK GLPQPTISFD GIYANVRMVH ILTSVVGSKC EVQVKNGGIY EGVFKTYSPK CDLVLDAAHE KSTESSSGPK REEIMESVLF KCSDFVVVQF KDTDSSYARR DAFTDSALSA KVNGEHKEKD LEPWDAGELT ASEELELEND VSNGWDPNDM FRYNEENYGV VSTYDSSLSS YTVPLERDNS EEFLKREARA NQLAEEIESS AQYKARVALE NDDRSEEEKY TAVQRNCSDR EGHGPNTRDN KYIPPGQRNR EVLSWGSGRQ SSPRMGQPGP GSMPSRAASH TSDFNPNAGS DQRVVNGGVP WPSPCPSHSS RPPSRYQSGP NSLPPRAATH TRPPSRPPSR PSRPPSHPSA HGSPAPVSTM PKRMSSEGPP RMSPKAQRHP RNHRVSAGRG SMSSGLEFVS HNPPSEAAAP PVARTSPAGG TWSSVVSGVP RLSPKTHRPR SPRQSSIGNS PSGPVLASPQ AGIIPAEAVS MPVPAASPTP ASPASNRALT PSIEAKDSRL QDQRQNSPAG SKENVKASET SPSFSKADNK GMSPVVSEHR KQIDDLKKFK NDFRLQPSST SESMDQLLSK NREGEKSRDL IKDKTEASAK DSFIDSSSSS SNCTSGSSKT NSPSISPSML SNAEHKRGPE VTSQGVQTSS PACKQEKDDR EEKKDTTEQV RKSTLNPNAK EFNPRSFSQP KPSTTPTSPR PQAQPSPSMV GHQQPAPVYT QPVCFAPNMM YPVPVSPGVQ PLYPIPMTPM PVNQAKTYRA GKVPNMPQQR QDQHHQSTMM HPASAAGPPI VATPPAYSTQ YVAYSPQQFP NQPLVQHVPH YQSQHPHVYS PVIQGNARMM APPAHAQPGL VSSSAAQFGA HEQTHAMYAC PKLPYNKETS PSFYFAISTG SLAQQYAHPN AALHPHTPHP QPSATPTGQQ QSQHGGSHPA PSPVQHHQHQ AAQALHLASP QQQSAIYHAG LAPTPPSMTP ASNTQSPQSS FPAAQQTVFT IHPSHVQPAY TTPPHMAHVP QAHVQSGMVP SHPTAHAPMM LMTTQPPGPK AALAQSALQP IPVSTTAHFP YMTHPSVQAH HQQQL Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: Ataxin 2 (ATXN2)

Alternative Name: Atxn2

Background: Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog),FUNCTION: Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}.

Molecular Weight: 136.5 kDa

UniProt: O70305

AlphaFold: O70305

Pathways: Ribonucleoprotein Complex Subunit Organization