CEP164 Protein (AA 1-1446) (His tag)

Catalog No. ABIN7563808

Product Details

Target: CEP164 (Centrosomal Protein 164kDa (CEP164))

Protein Type: Recombinant

Protein Characteristics: AA 1-1446

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This CEP164 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Cep164 Protein expressed in mammalian cells.

Sequence: MARRPILLGD QLVLEEDSDE TYVPSEQEIL DFARVIGIDP IKEPELMWLA REGIEAPLPK GWKPCQNITG DLYYFNFDTG QSIWDHPCDE HYRKLVIQER ERWSAPGAIK KKDKKKKKEK KNKKDKETSK SPLVLGSPLA LVQAPLWGLA PLRGLGDAPP SALRGSQSVS LGSSADSGHL GEPTLPPQGL KAAACAKGLL ASVHEGKNAL SLLTLGEETN EEDEEESDNQ SVRSSSELLK NLHLDLGALG GNFEYEESPR TSQPDKKDVS LDSDADRPPT PGKLFSQGAD SSVASANGSK SQGRGASPWN PQKENENSDP KASSSQMAPE LDPGGDQPSR ASKKQQAEDP VQAGKEGECR RESAAKEPKE ASALENTSDV SEESEIHGHL KDARHSGSEA SGPKSFLGLD LGFRSRISEH LLDGDTLSPV LGGGHWEAQG LDQEEQDDSK SSIAEPQSKH TQGSEREHLQ SSLHSQATEE GPLQTLEGQP EWKEAEGPGK DSVASPAPLS LLQREQVLSP PASPERAEEK HSQAEELGLE QPEAEETEEK VAVCPSSPVS PEVQTAEPAA PQKLFSEAIL KGMELEEDQR LLLEFQKEKP QQLEERLWEE EEEEVCQLYQ QKEKSLSLLK AQLQKATAEE KEKEEETKIR EEESRRLVCL RAQVQSRTEA FENQIRTEQQ AALQRLREEA ETLQKAERAS LEQKSRRALE QLREQLEAEE RSAQAALRAE KEAEKEAALL QLREQLEGER KEAVAGLEKK HSAELEQLCS SLEAKHQEVI SSLQKKIEGA QQKEEAQLQE SLGWAEQRAH QKVHQVTEYE QELSSLLRDK RQEVEREHER KMDKMKEEHW QEMADARERY EAEERKQRAD LLGHLTGELE RLRRAHEREL ESMRQEQDQQ LEDLRRRHRD HERKLQDLEV ELSSRTKDVK ARLAQLNVQE ENIRKEKQLL LDAQRQAALE REEATATHQH LEEAKKEHTH LLETKQQLRR TIDDLRVRRV ELESQVDLLQ AQSQRLQKHL SSLEAEVQRK QDVLKEMAAE MNASPHPEPG LHIEDLRKSL DTNKNQEVSS SLSLSKEEID LSMESVRQFL SAEGVAVRNA KEFLVRQTRS MRRRQTALKA AQQHWRHELA SAQEVDEDLP GTEVLGNMRK NLNEETRHLD EMKSAMRKGH DLLKKKEEKL IQLESSLQEE VSDEDTLKGS SIKKVTFDLS DMDDLSSESL ESSPVLHITP TPTSADPNKI HYLSSSLQRI SSELNGVLNV LGSLNSQPPP QGLGSQPPPP LFTSSLRSSK NVLDPAYSSQ AKLSSLSSIT PMSTQWAWDP GQGTKLTSSS SSQTVDDFLL EKWRKYFPSG IPLLSGSPPP PENKLGYVSV SEQLHFLQRS HPRVPRTDGV SIQSLIDSNR KWLEHFRNDP KVQLFSSAPK ATTTSNLSNL LQLGLDENNR LNVFHY Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: CEP164 (Centrosomal Protein 164kDa (CEP164))

Alternative Name: Cep164 (CEP164 Products)

Background: Centrosomal protein of 164 kDa (Cep164),FUNCTION: Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:22863007}.

Molecular Weight: 162.6 kDa

UniProt: Q5DU05

AlphaFold: Q5DU05

Pathways: M Phase