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HIRA Protein (AA 1-1015) (His tag)

This Recombinant HIRA protein is produced in HEK-293 Cells.
Catalog No. ABIN7563928

Quick Overview for HIRA Protein (AA 1-1015) (His tag) (ABIN7563928)

Target

See all HIRA Proteins
HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

Protein Type

Recombinant

Origin

  • 4
  • 1
Mouse

Source

  • 2
  • 2
  • 1
HEK-293 Cells

Purity

> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade

custom-made
  • Protein Characteristics

    AA 1-1015

    Purification tag / Conjugate

    This HIRA protein is labelled with His tag.

    Purpose

    Predefined custom protein recombinant Hira Protein expressed in mammalian cells.

    Sequence

    MKLLKPTWVN HNGKPIFSVD IHPDGTKFAT GGQGQDSGKV VIWNMSPVLQ EDDEKDENIP KMLCQMDNHL ACVNCVRWSN SGMYLASGGD DKLIMVWKRA TYIGPSTVFG SSGKLANVEQ WRCVSILRSH SGDVMDVAWS PHDAWLASCS VDNTVVIWNA VKFPEILATL RGHSGLVKGL TWDPVGKYIA SQADDRSLKV WRTLDWQLET SITKPFDECG GTTHVLRLSW SPDGHYLVSA HAMNNSGPTA QIIEREGWKT NMDFVGHRKA VTVVKFNPKI FKKKQKNGSS TKPSCPYCCC AVGSKDRSLS VWLTCLKRPL VVIHELFDKS IMDISWTLNG LGILVCSMDG SVAFLDFSQD ELGDPLSEEE KSRIHQSTYG KSLAIMTEAQ LSTAVIENPE MLKYQRRQQQ QQLDQKNATT RETSSASSVT GVVNGESLED IRKNLLKKQV ETRTADGRRR ITPLCIAQLD TGDFSTAFFN SIPLSSSLAG TMLSSPSGQQ LLPLDSSTPS FGASKPCTEP VAATSARPTG ESVSKDSMNA TSTPAASSPS VLTTPSKIEP MKAFDSRFTE RSKATPGAPS LTSVIPTAVE RLKEQNLVKE LRSRELESSS DSDEKVHLAK PSSLSKRKLE LEVETVEKKK KGRPRKDSRL LPMSLSVQSP AALSTEKEAM CLSAPALALK LPIPGPQRAF TLQVSSDPSM YIEVENEVTT VGGIRLSRLK CNREGKEWET VLSSRVLTAA GSCDVVCVAC EKRMLSVFST CGRRLLPPIL LPSPISTLHC TGPYVMALTA AATLSVWDVH RQVVVVKEES LHSILSGSDM TVSQILLTQH GIPVMNLSDG KAYCFNPSLS TWNLVSDKQD SLAQCADFRN SLPSQDAMLC SGPLAIIQGR TSNSGRQAAR LFSVPHVVQQ ETTLAYLENQ VAAALTLQSS HEYRHWLLLY ARYLVNEGFE YRLREICKDL LGPVHCSTGS QWESTVVGLR KRELLKELLP VIGQNLRFQR LFTECQEQLD ILRDK Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

    Specificity

    If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

    Characteristics

    Key Benefits:
    • Predefined custom protein - from design to production - by highly experienced protein experts.
    • Protein expressed in mammalian cells and purified in one-step affinity chromatography
    • The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
    • State-of-the-art algorithm used for plasmid design (Gene synthesis).
    This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

    If you are not interested in a full length protein, please contact us for individual protein fragments.

    The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.
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  • Application Notes

    We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    The buffer composition is at the discretion of the manufacturer.

    Handling Advice

    Avoid repeated freeze-thaw cycles.

    Storage

    -80 °C

    Storage Comment

    Store at -80°C.

    Expiry Date

    12 months
  • Target

    HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

    Alternative Name

    Hira

    Background

    Protein HIRA (TUP1-like enhancer of split protein 1),FUNCTION: Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000250, ECO:0000269|PubMed:16399082}.

    Molecular Weight

    111.8 kDa

    UniProt

    Q61666

    AlphaFold

    Q61666

    Pathways

    Chromatin Binding
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