TAO Kinase 2 Protein (TAOK2) (AA 1-1240) (His tag)

Catalog No. ABIN7564168

This Recombinant TAO Kinase 2 protein is produced in HEK-293 Cells.

Quick Overview for TAO Kinase 2 Protein (TAOK2) (AA 1-1240) (His tag) (ABIN7564168)

Target: TAO Kinase 2 (TAOK2)

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-1240

Purification tag / Conjugate: This TAO Kinase 2 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Taok2 Protein expressed in mammalian cells.

Sequence: MPAGGRAGSL KDPDVAELFF KDDPEKLFSD LREIGHGSFG AVYFARDVRN SEVVAIKKMS YSGKQSNEKW QDIIKEVRFL QKLRHPNTIQ YRGCYLREHT AWLVMEYCLG SASDLLEVHK KPLQEVEIAA VTHGALQGLA YLHSHNMIHR DVKAGNILLS EPGLVKLGDF GSASIMAPAN SFVGTPYWMA PEVILAMDEG QYDGKVDVWS LGITCIELAE RKPPLFNMNA MSALYHIAQN ESPALQSGHW SEYFRNFVDS CLQKIPQDRP TSEVLLKHRF VLRERPPTVI MDLIQRTKDA VRELDNLQYR KMKKILFQEA PNGPGAEAPE EEELTPCSQE AEPYTHRAGT LTSLESSHSV PSMSISASSQ SSSVNSLADA SDNEEEEEEE EEEEEEEEEE GPESREMAMM QEGEHTVTSH SSIIHRLPGS DNLYDDPYQP EMTPGPLQPP AAPPTSTSSS ARRRAYCRNR DHFATIRTAS LVSRQIQEHE QDSALREQLS GYKRMRRQHQ KQLLALESRL RGEREEHSGR LQRELEAQRA GFGTEAEKLA RRHQAIGEKE ARAAQAEERK FQQHILGQQK KELAALLEAQ KRTYKLRKEQ LKEELQENPS TPKREKAEWL LRQKEQLQQC QAEEEAGLLR RQRQYFELQC RQYKRKMLLA RHSLDQDLLR EDLNKKQTQK DLECALLLRQ HEATRELELR QLQAVQRTRA ELTRLQHQTE LGNQLEYNKR REQELRQKHA AQVRQQPKSL KVRAGQLPMG LPATGALGPL STGTPSEEQP CSSGQEAILD QRMLGEEEEA VPERRILGKE GTTLEPEEQR ILGEEMGTFS SSPQKHRSLA NEEDWDISEE MKEIRVPSLA SQERNIIGQE EAAAWSLWEK EGGNLVDVEF KLGWVQGPVL TPVPEEEEEE EEEGGAPIGT HRDPGDGCPS PDIPPEPPPS HLRQYPTSQL PGLLSHGLLA GLSFAVGSSS GLLPLLLLLL LPLLAAQGGG GLQAALLALE VGLVGLGASY LFLCTALHLP PGLFLLLAQG TALLAVLSLS WRRGLMGVPL GLGAAWLLAW PSLALPLAAM AAGGKWVRQQ GPQMRRGISR LWLRILLRLS PMVFRALQGC GAVGDRGLFA LYPKTNKNGF RSRLPVPWPR QGNPRTTQHP LAQLTRVWAV CKGWNWRLAR ASHRLASCLP PWAVHILASW GLLKGERPSR IPRLLPRSQR RLGLSASRQL PPGTVAGRRS QTRRTLPPWR Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: TAO Kinase 2 (TAOK2)

Alternative Name: Taok2

Background: Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2),FUNCTION: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14/p38 MAPK activation (By similarity). {ECO:0000250}.

Molecular Weight: 139.3 kDa

UniProt: Q6ZQ29

AlphaFold: Q6ZQ29

Pathways: Cell-Cell Junction Organization