ADC Protein (AA 1-459) (His tag)

Catalog No. ABIN7564437

Recombinant ADC protein expressed in HEK-293 Cells.

Quick Overview for ADC Protein (AA 1-459) (His tag) (ABIN7564437)

Target: ADC (Arginine Decarboxylase (ADC))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-459

Purification tag / Conjugate: This ADC protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Azin2 Protein expressed in mammalian cells.

Sequence: MAGYLSESDF VMVEEGFSTR DLLEELTLGA SQATSGKVAA FFVADLGAVV RKHFCFLKHL PRVRPFYAVG CNSSLGVLKV LAELGLGFSC ANKAEMELVQ HIGVPASKII CANPCKQVAQ IKYAAKHGVR LLSFDNEVEL AKVVKSHPSA KMVLCIATQD SHSLNHLSLR FGASLKSCRH LLENAKKSHV EVVGVSFHIG SGCPDPQAYA QSIADARLVF QMGEELGHTM NILDLGGGFP GLEGAKVRFE EMASVINSAL DLYFPEGCGV DILAELGRYY VTSAFTVAVS IVAKREVLDQ ASREEQTGAA PKSIVYYLDE GVYGVFNSVL FDNTCPTPAL QKKPSADQPL YSSSLWGPAV EGCDCVAEGL WLPQLQVGDW LVFDNMGAYT VDTKSLLGGT QARRVTYAMS RLAWEALRGQ LLPAEEDQDA EGVCKPLSCG WEITDTLCVG PVFTPASIM Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: ADC (Arginine Decarboxylase (ADC))

Alternative Name: Azin2

Background: Antizyme inhibitor 2 (AzI2) (Arginine decarboxylase-like protein) (ADC) (ARGDC) (Ornithine decarboxylase-like protein) (ODC-like protein) (ornithine decarboxylase paralog) (ODC-p),FUNCTION: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:18062773, PubMed:18508777, PubMed:18973822). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:16916800, PubMed:24967154). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q96A70, ECO:0000269|PubMed:16916800, ECO:0000269|PubMed:18062773, ECO:0000269|PubMed:18508777, ECO:0000269|PubMed:18973822, ECO:0000269|PubMed:24967154}.

Molecular Weight: 49.5 kDa

UniProt: Q8BVM4

AlphaFold: Q8BVM4