P2RX2 Protein (AA 1-485) (His tag)

Catalog No. ABIN7564655

Product Details

Target: P2RX2 (Purinergic Receptor P2X, Ligand Gated Ion Channel 2 (P2RX2))

Protein Type: Recombinant

Protein Characteristics: AA 1-485

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This P2RX2 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant P2rx2 Protein expressed in mammalian cells.

Sequence: MAAAQPRLPA GAAMVRRLAR GCWSAFWDYE TPKVIVVRNR RLGFVHRMVQ LLILLYFVWY VFIVQKSYQD SETGPESSII TKVKGITMSE HKVWDVEEYV KPPEGGSVVS IITRIEVTPS QTLGTCPESM RVHSSTCHLD DDCVAGQLDM QGNGIRTGRC VPYYHGDSKT CEVSAWCPVE DGTSENHFLG KMAPNFTILI KNSIHYPKFK FSKGNIASQK SDYLKHCTFD QDSDPYCPIF RLGFIVEQAG ENFTELAHKG GVIGVIINWN CDLDLSESEC NPKYSFRRLD PKYDPASSGY NFRFAKYYKI NGTTTTRTLI KAYGIRIDVI VHGQAGKFSL IPTIINLATA LTSIGVGSFL CDWILLTFMN KNKLYSHKKF DKVRTPRHPS SRWPVTLALV LGQIPPPPSH YSQDQPPSLP SGEGPALGEG AELPLAVQPP RSCSSSALTE QVVDTLDQHM GQRPPVPEPS QQDSTSTDPK GLAQL Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: P2RX2 (Purinergic Receptor P2X, Ligand Gated Ion Channel 2 (P2RX2))

Alternative Name: P2rx2 (P2RX2 Products)

Background: P2X purinoceptor 2 (P2X2) (ATP receptor) (Purinergic receptor),FUNCTION: Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. {ECO:0000269|PubMed:12917379, ECO:0000269|PubMed:12937291, ECO:0000269|PubMed:15961431, ECO:0000269|PubMed:16322458, ECO:0000269|PubMed:17706883, ECO:0000269|PubMed:23345450}.

Molecular Weight: 53.9 kDa

UniProt: Q8K3P1

AlphaFold: Q8K3P1

Pathways: Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity