OAS3 Protein (AA 1-1138) (His tag)

Catalog No. ABIN7564771

This Recombinant OAS3 protein is produced in HEK-293 Cells.

Quick Overview for OAS3 Protein (AA 1-1138) (His tag) (ABIN7564771)

Target: OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-1138

Purification tag / Conjugate: This OAS3 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Oas3 Protein expressed in mammalian cells.

Sequence: MDLFHTPAGA LDKLVAHNLH PAPEFTAAVR GALGSLNITL QQHRARGSQR PRVIRIAKGG AYARGTALRG GTDVELVIFL DCFQSFGDQK TCHSETLGAM RMLLESWGGH PGPGLTFEFS QSKASRILQF RLASADGEHW IDVSLVPAFD VLGQPRSGVK PTPNVYSSLL SSHCQAGEYS ACFTEPRKNF VNTRPAKLKN LILLVKHWYH QVQTRAVRAT LPPSYALELL TIFAWEQGCG KDSFSLAQGL RTVLALIQHS KYLCIFWTEN YGFEDPAVGE FLRRQLKRPR PVILDPADPT WDVGNGTAWR WDVLAQEAES SFSQQCFKQA SGVLVQPWEG PGLPRAGILD LGHPIYQGPN QALEDNKGHL AVQSKERSQK PSNSAPGFPE AATKIPAMPN PSANKTRKIR KKAAHPKTVQ EAALDSISSH VRITQSTASS HMPPDRSSIS TAGSRMSPDL SQIPSKDLDC FIQDHLRPSP QFQQQVKQAI DAILCCLREK SVYKVLRVSK GGSFGRGTDL RGSCDVELVI FYKTLGDFKG QKPHQAEILR DMQAQLRHWC QNPVPGLSLQ FIEQKPNALQ LQLASTDLSN RVDLSVLPAF DAVGPLKSGT KPQPQVYSSL LSSGCQAGEH AACFAELRRN FINTCPPKLK SLMLLVKHWY RQVVTRYKGG EAAGDAPPPA YALELLTIFA WEQGCGEQKF SLAEGLRTIL RLIQQHQSLC IYWTVNYSVQ DPAIRAHLLC QLRKARPLVL DPADPTWNVG QGDWKLLAQE AAALGSQVCL QSGDGTLVPP WDVTPALLHQ TLAEDLDKFI SEFLQPNRHF LTQVKRAVDT ICSFLKENCF RNSTIKVLKV VKGGSSAKGT ALQGRSDADL VVFLSCFRQF SEQGSHRAEI ISEIQAHLEA CQQMHSFDVK FEVSKRKNPR VLSFTLTSQT LLDQSVDFDV LPAFDALGQL RSGSRPDPRV YTDLIHSCSN AGEFSTCFTE LQRDFITSRP TKLKSLIRLV KYWYQQCNKT IKGKGSLPPQ HGLELLTVYA WEQGGQNPQF NMAEGFRTVL ELIVQYRQLC VYWTINYSAE DKTIGDFLKM QLRKPRPVIL DPADPTGNLG HNARWDLLAK EATVYASALC CVDRDGNPIK PWPVKAAV Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))

Alternative Name: Oas3

Background: 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (2',5'-oligoadenylate synthetase-like 10),FUNCTION: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:12396720}.

Molecular Weight: 126.3 kDa

UniProt: Q8VI93

AlphaFold: Q8VI93

Pathways: Hepatitis C