CARD14 Protein (AA 1-999) (His tag)

Catalog No. ABIN7564886

Product Details

Target: CARD14 (Caspase Recruitment Domain Family, Member 14 (CARD14))

Protein Type: Recombinant

Protein Characteristics: AA 1-999

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This CARD14 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Card14 Protein expressed in mammalian cells.

Sequence: MAELCRMDST LTALDEEMLW DMLESHRCRI VQSICPSRLT PYLRQAKVLG QLDEEEILHS SRFTNSAMRV GHLLDLLKAR GKNGAIAFLE SLKFHNPDVY TLVTGLQSDI DFSTFSGLME TSKLTECLAG AISSLQEELA QEKAQKEVLL RRCQQLKERL GLAEAHAEGL RQLEVDHSRM KREVSTHFHE VLKLKDEMLN LSLHYSNALR EKELAATRCH SLQEELYLVK QELQRASLVS SCERESRERS LKMASNLEPQ GEELNRLKEE NEKLRSMTFS LVEKDILEQS LDEARESKQE LVDRIHSLRE RAVAAERQQK QYWEEKEQTL LQFRKTQVDC ELYKEKMTML QGQVAELQKE RDQAYTARDR AQMEISQRLV EKDALRRRVF ELTEQVCELR TQLRRLQAEA PGGPKQEAGA RELCLRGKQR LVRMHAVCPP DDSDCSLLSS TESRLWWDLN STSSREQMDS FRSSSPMPPS QQSLYKRVAE DFLEDPESLS FPEVLEMRLQ GATVDDTDTD LEFEMIDGAD LSQTEDSLQG SSRSLNVSES SVPVRRRPAR KILSQVTVLA FQGDALLEQI GVIGGNLTGI FIHRVTPGSA ADEMALRPGT QIMMVDYKPT KPSLRATLEN TTLEQAVGLL RRVNGSCYLS VKINTEGYKN LIQDLDAKVV TSGDSFYIRV NLAMQRGGDG ELQTHCNDIL HVTDTMFQGR SCWHAHHVNP YTMKDMEPGT IPNYSQAQQQ LLALIQDMTQ RCTVPRKPPG GPQKLVRIVS VDKAAVSPLT SSFDQSQWDS GKEEGGPSVC FWSESCFTLA PYTLVHPHRP ARPRPVLFVP RLVGRILGKK LCLLQGFKQC SAEYLSQEEY ATWSQRGDII QEGESIGDHH WITRHAVESL MNMSTHALLD VRLDSVRVLH RMDMFPIIIH VSVNEKTAKK LRKGLHRLGS SEEQFLEVAR QEEGELDRVP CLYSSLAPDS WSDLDSLLSC VRLAIADEQK KVVWTESPC Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: CARD14 (Caspase Recruitment Domain Family, Member 14 (CARD14))

Alternative Name: Card14 (CARD14 Products)

Background: Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2),FUNCTION: Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000250|UniProtKB:Q9BXL6}.

Molecular Weight: 113.5 kDa

UniProt: Q99KF0

AlphaFold: Q99KF0